New pharmaceuticals approved by FDA in 2020: Small-molecule drugs derived from amino acids and related compounds.
Aiyao LiuJianlin HanArina NakanoHiroyuki KonnoHiroki MoriwakiHidenori AbeKunisuke IzawaVadim A SoloshonokPublished in: Chirality (2021)
Amino acids (AAs) play an important role in the modern health industry as key synthetic precursors for pharmaceuticals, biomaterials, biosensors, and drug delivery systems. Currently, over 30% of small-molecule drugs contain residues of tailor-made AAs or derived from them amino-alcohols and di-amines. In this review article, we profile 12 AA-derived new pharmaceuticals approved by the FDA in 2020. These newly introduced drugs include Tazverik (epithelioid sarcoma), Gemtesa (overactive bladder), Zeposia (multiple sclerosis), Byfavo (induction and maintenance of procedural sedation), Cu 64 dotatate, and Gallium 68 PSMA-11 (both PET imaging), Rimegepant (acute migraine), Zepzelca (lung cancer), Remdesivir (COVID-19), Amisulpride (nausea and vomiting), Setmelanotide (obesity), and Lonafarnib (progeria syndrome). For each compound, we describe the spectrum of biological activity, medicinal chemistry discovery, and synthetic preparation.
Keyphrases
- small molecule
- pet imaging
- amino acid
- multiple sclerosis
- protein protein
- pet ct
- drug induced
- sars cov
- coronavirus disease
- liver failure
- metabolic syndrome
- insulin resistance
- public health
- drug administration
- positron emission tomography
- type diabetes
- mental health
- weight loss
- respiratory failure
- case report
- computed tomography
- weight gain
- adipose tissue
- tissue engineering
- molecularly imprinted
- escherichia coli
- skeletal muscle
- biofilm formation
- white matter
- risk assessment
- high throughput
- body mass index
- neuroendocrine tumors
- social media
- acute respiratory distress syndrome
- metal organic framework