Impact of oral anticoagulation on clinical outcomes of COVID-19: a nationwide cohort study of hospitalized patients in Germany.
Georg Marcus FröhlichElke JeschkeUwe EichlerHolger ThieleLaila AlhaririMarkus ReinthalerAdnan KastratiDavid Manuel LeistnerCarsten SkurkUlf LandmesserChristian GünsterPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2021)
In a multivariable analysis, a therapy with both direct oral anticoagulants or vitamin-K antagonists-but not with antiplatelet therapy-was associated with improved clinical outcomes. ACE inhibitors did not impact outcomes. Prospective randomized trials are needed to verify this hypothesis.
Keyphrases
- antiplatelet therapy
- direct oral anticoagulants
- venous thromboembolism
- atrial fibrillation
- percutaneous coronary intervention
- acute coronary syndrome
- coronavirus disease
- sars cov
- angiotensin ii
- coronary artery disease
- stem cells
- angiotensin converting enzyme
- mesenchymal stem cells
- bone marrow
- skeletal muscle
- replacement therapy