Long-term potentiation-like cortical plasticity is disrupted in Alzheimer's disease patients independently from age of onset.

Francesco Di LorenzoViviana PonzoSonia BonnìCaterina MottaPriscilla C Negrão SerraMarco BozzaliCarlo CaltagironeAlessandro MartoranaGiacomo Koch

Published in: Annals of neurology (2016)

Cortical LTP disruption is a central mechanism of AD that is independent from age of onset. AD can be described primarily as a disorder of LTP-like cortical plasticity not influenced by physiological aging and associated with a more-severe cognitive decline. Ann Neurol 2016;80:202-210.

Keyphrases

cognitive decline
mild cognitive impairment
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
early onset
neural network