Lyophilization stabilizes clinical-stage core-crosslinked polymeric micelles to overcome cold chain supply challenges.

Tarun OjhaQizhi HuClaudio ColomboJan WitMichiel van GeijnMies J van SteenbergenMahsa BagheriHiltrud Königs-WernerEva Miriam BuhlRuchi BansalYang ShiWim E HenninkGert StormCristianne J F RijckenTwan Lammers

Published in: Biotechnology journal (2021)

Our findings provide proof-of-concept for the lyophilization of drug-containing CCPM and our methodology is readily translatable to large-scale manufacturing for future commercialization.

Keyphrases

drug delivery
drug release
cancer therapy
hyaluronic acid
current status
emergency department
adverse drug
drug induced