DPPA3 facilitates genome-wide DNA demethylation in mouse primordial germ cells.

Keisuke ToriyamaWan Kin Au YeungAzusa InoueKazuki KurimotoYukihiro YabutaMitinori SaitouToshinobu NakamuraToru NakanoHiroyuki Sasaki

Published in: BMC genomics (2024)

The results suggest that DPPA3 facilitates DNA demethylation through a replication-coupled passive mechanism in PGCs. Our study identifies DPPA3 as a novel epigenetic reprogramming factor in mouse PGCs.

Keyphrases

genome wide
dna methylation
circulating tumor
cell free
induced apoptosis
single molecule
gene expression
cell cycle arrest
nucleic acid
oxidative stress
cell death
germ cell