Photo-Enhanced Chemo-Transistor Platform for Ultrasensitive Assay of Small Molecules.
Qiankun WangZhaolin AiQianying GuoXuejun WangChanghao DaiHancheng WangJiang SunYanan TangDingding JiangXinjie PeiRenzhong ChenJian GouLin YuJiandong DingAndrew Thye Shen WeeYunqi LiuDacheng WeiPublished in: Journal of the American Chemical Society (2023)
Compared with traditional assay techniques, field-effect transistors (FETs) have advantages such as fast response, high sensitivity, being label-free, and point-of-care detection, while lacking generality to detect a wide range of small molecules since most of them are electrically neutral with a weak doping effect. Here, we demonstrate a photo-enhanced chemo-transistor platform based on a synergistic photo-chemical gating effect in order to overcome the aforementioned limitation. Under light irradiation, accumulated photoelectrons generated from covalent organic frameworks offer a photo-gating modulation, amplifying the response to small molecule adsorption including methylglyoxal, p -nitroaniline, nitrobenzene, aniline, and glyoxal when measuring the photocurrent. We perform testing in buffer, artificial urine, sweat, saliva, and diabetic mouse serum. The limit of detection is down to 10 -19 M methylglyoxal, about 5 orders of magnitude lower than existing assay technologies. This work develops a photo-enhanced FET platform to detect small molecules or other neutral species with enhanced sensitivity for applications in fields such as biochemical research, health monitoring, and disease diagnosis.
Keyphrases
- label free
- high throughput
- small molecule
- electron transfer
- type diabetes
- photodynamic therapy
- public health
- cancer therapy
- gold nanoparticles
- combination therapy
- social media
- single cell
- drug delivery
- squamous cell carcinoma
- mass spectrometry
- radiation induced
- health information
- wound healing
- high resolution
- climate change
- liquid chromatography
- rectal cancer