Stromal-Like Cells Are Found in Peripheral Blood of Patients With Inflammatory Bowel Disease and Correlate With Immune Activation State.

Amanda M HonanGillian E JacobsenHannah DrumEmily N VazquezMaria A QuinteroAmar R DeshpandeDaniel A SussmanDavid H KermanOriana M DamasSiobhan ProksellKevin Van der JeughtMaria T AbreuZhibin Chen

Published in: Clinical and translational gastroenterology (2024)

These observations suggest that PDPN + cells in the blood may serve as a biomarker of IBD. Understanding the relationship between stromal cells and immune cells in the intestine and the blood may provide a window into disease pathogenesis and insight into therapeutic targets for IBD.

Keyphrases

patients with inflammatory bowel disease
peripheral blood
induced apoptosis
cell cycle arrest
bone marrow
ulcerative colitis
endoplasmic reticulum stress
oxidative stress
cell death
pi k akt