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Anti-photoaging activity of triterpenoids isolated from Centella asiatica.

Yi-Yun DangTao LiuYu-Die LiuJia-Yi LiYi JingMiao-Jie YangHan ZhangMiao-Miao JiangHong-Hua WuWen-Zhi YangNan LiPeng Zhang
Published in: Phytochemistry (2024)
Centella asiatica (L.) Urban is a medical plant rich in triterpenoids, frequently used in Asia to treat skin conditions such as acne. To search for anti-photoaging agents, 16 known triterpenoids and five undescribed triterpenoids, including three ursane, one oleanane and one nor-ursane were isolated from the whole herb of C. asiatica. The structures and relative stereochemistry of these compounds were elucidated by detailed NMR spectra and HRESIMS. Compounds 1 and 2 were isomers of ursane-type and oleane-type triterpenes with rare aldehyde groups on C-23. Compound 4 was a unique example of a nor-ursane type triterpenoid. The Ultraviolet B (UVB) induced HaCaT cell damage model was used to measure the in vitro anti-photoaging activity of all 21 compounds. Twenty compounds significantly increased HaCaT viability and inhibited lactate dehydrogenase (LDH) release after UVB exposure. These findings highlight the protective effects of C. asiatica-derived triterpenoids against UVB damage and indicate their potential as natural agents that can protect the skin against photoaging.
Keyphrases
  • oxidative stress
  • high resolution
  • soft tissue
  • single cell
  • wound healing
  • diabetic rats
  • stem cells
  • high glucose