Clozapine and COVID-19 Vaccination: Effects on blood levels and leukocytes. An observational cohort study.
Selene R T VeermanTimo MoscouJan P A M BogersDan CohenPeter F J SchultePublished in: Acta psychiatrica Scandinavica (2022)
In general, as regards WBC counts COVID-19 vaccination seems to be safe in patients with SMI. Changes in WBC had no clinical implications. Psychoeducation on the symptoms of clozapine intoxication is recommended, especially in patients with clozapine blood levels approaching the upper limit of the therapeutic range. Increase in the C-reactive protein (CRP) level can signal inflammation rapidly and help to prevent clozapine intoxication following vaccination.