Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments.

Janice YangNeil J DailyTaylor K PullingerTetsuro WakatsukiEric A Sobie

Published in: bioRxiv : the preprint server for biology (2024)

: the full process of iPSC-CM computational model calibration; Includes iPSC-CM data acquisition/simulation -> data processing -> parameter calibration using genetic algorithm -> validation of calibrated models on an unseen condition (i.e. evaluating model predictions).

Keyphrases

stem cells
electronic health record
big data
machine learning
cell therapy
high resolution
deep learning
low cost
gene expression
copy number
induced pluripotent stem cells
mesenchymal stem cells
high glucose