Plasma Biomarkers of Brain Injury and Their Association With Brain MRI and Cognition in Type 1 Diabetes.
Amy B KargerIlya M NasrallahBarbara H BraffettJosé A LuchsingerChristopher M RyanIonut BebuValerie ArendsMohamad HabesRose A Gubitosi-KlugNaomi S ChaytorGeert Jan BiesselsAlan M Jacobsonnull nullPublished in: Diabetes care (2024)
In this aging T1D cohort, biomarkers of brain injury did not demonstrate an AD-like profile. NfL emerged as a biomarker of interest in T1D because of its association with higher HbA1c, accelerated brain aging on MRI, and cognitive dysfunction. Our study suggests that early neurodegeneration in adults with T1D is likely due to non-AD/nonamyloid mechanisms.
Keyphrases
- brain injury
- cerebral ischemia
- subarachnoid hemorrhage
- white matter
- type diabetes
- contrast enhanced
- resting state
- magnetic resonance imaging
- diffusion weighted imaging
- functional connectivity
- cardiovascular disease
- glycemic control
- insulin resistance
- computed tomography
- magnetic resonance
- adipose tissue
- skeletal muscle