Evaluating Tumor Hypoxia Radiosensitization Via Electron Paramagnetic Resonance Oxygen Imaging (EPROI).

Ashlyn G RickardYvonne M MoweryAlex BassilDouglas C RouseNerissa T WilliamsTheresa CharityRafaela BelloniBrian CrouchNimmi RamanujamDaniel StevensonRico CastilloStephanie BlockerBoris EpelMrignayani KotechaGregory M Palmer

Published in: Molecular imaging and biology (2023)

quantification; EPR is better suited than DRS to characterize tumor hypoxia. PPV did not radiosensitize E0771 tumors nor p53/MCA sarcomas, which may be related to the complex pattern of vasculature in each tumor. Additionally, understanding model-dependent tumor hypoxia will provide a much-needed foundation for future therapeutic studies with hypoxic radiosensitizers.

Keyphrases

endothelial cells
high resolution
high grade
current status
fluorescence imaging