Mechanisms of Obesity-Induced Changes in Pharmacokinetics of IgG in Rats.

Xizhe GaoYi-Hua ShengSijia YuJiadong LiRaymond RosaSimone GirgisTiffany GuoLuigi BrunettiLeonid Kagan

Published in: Pharmaceutical research (2023)

We identified important obesity-induced changes in the pharmacokinetics of IgG. Results can potentially facilitate optimization of the dosing of IgG-based therapeutics in the obese population.

Keyphrases

weight loss
metabolic syndrome
insulin resistance
type diabetes
high fat diet induced
weight gain
bariatric surgery
adipose tissue
small molecule
obese patients
skeletal muscle
physical activity