MitoTam induces ferroptosis and increases radiosensitivity in head and neck cancer cells.
F V ReinemaN HudsonG J AdemaW J M PeetersJ NeuzilJ StursaL WernerF C G J SweepJ BussinkP N SpanPublished in: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2024)
Radiotherapy is applied in the treatment of a majority of cancer patients. Radioresistance due to elevated antioxidant levels can be overcome by promoting ferroptotic cell death combining ROS-inducing drug MitoTam with radiotherapy.
Keyphrases
- cell death
- early stage
- locally advanced
- cell cycle arrest
- radiation therapy
- radiation induced
- dna damage
- rectal cancer
- anti inflammatory
- emergency department
- combination therapy
- squamous cell carcinoma
- reactive oxygen species
- cell proliferation
- dna damage response
- signaling pathway
- smoking cessation
- electronic health record