Comparison of acid-lowering drugs for endoscopy negative reflux disease: Systematic review and network Meta-Analysis.

Brigida Barberio Pierfrancesco Visaggi Edoardo Vincenzo Savarino Nicola de Bortoli Christopher J Black Alexander Charles Ford

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2022)

Our results confirm superiority of PPIs compared with most other drugs in treating endoscopy-negative reflux disease. Future RCTs should aim to better classify patients with endoscopy-negative reflux disease, and to establish the role of alginates and PCABs in achieving symptom relief in both the short- and long-term.

Keyphrases

small bowel
drug induced