Associations of circulating choline and its related metabolites with cardiometabolic biomarkers: an international pooled analysis.
Xiong-Fei PanJae Jeong YangXiao-Ou ShuSteven C MooreNicholette D PalmerMarta Guasch-FerreDavid M HerringtonSei HaradaHeather EliassenThomas J WangRobert E GersztenDemetrius AlbanesJoanna TzoulakiIbrahim KaramanPaul ElliottHuilian ZhuLynne E WagenknechtWei ZhengHui CaiQiuyin CaiCharles E MatthewsCristina MenniKatie A MeyerLoren P LipworthJennifer OseMyriam FornageCornelia M UlrichDanxia YuPublished in: The American journal of clinical nutrition (2021)
Circulating choline, carnitine, and DMG were associated with unfavorable cardiometabolic risk profiles, whereas circulating betaine was associated with a favorable cardiometabolic risk profile. Future prospective studies are needed to examine the associations of these metabolites with incident cardiovascular events.