Neutrophil Extracellular Trap Density Increases With Increasing Histopathological Severity of Crohn's Disease.
Angie L SchroderBelal ChamiYuyang LiuChloe M DoyleMary El KazziGolo AhlenstielGulfam AhmadNimalan Pathma-NathanGeoff CollinsJames TohAndrew HarmanScott ByrneGrahame CterctekoPaul K WittingPublished in: Inflammatory bowel diseases (2021)
These data indicate an association between increased NET formation and CD severity, potentially due to excessive MPO-mediated HOCl production in the extracellular domain, causing host tissue damage that exacerbates CD.