Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments.

María Del Mar Fernández-ArjonaJuan Antonio NavarroAntonio Jesús López-GamberoMarialuisa de CegliaMiguel RodríguezLeticia RubioFernando Rodríguez de FonsecaVicente BarriosJulie A ChowenJesús ArgentePatricia RiveraJuan Suarez

Published in: Biology of sex differences (2024)

Sex-specific differences in IGF1 system and signaling pathways are associated with Pappa2 deficiency, pointing to rhPAPP-A2 as a promising drug to alleviate postnatal growth retardation underlying low IGF1 bioavailability in a female-specific manner.

Keyphrases

pi k akt
signaling pathway
binding protein
growth hormone
preterm infants
emergency department
epithelial mesenchymal transition
smoking cessation
adverse drug