Glucose degradation products in peritoneal dialysis solution impair angiogenesis by dysregulating angiogenetic factors in endothelial and vascular smooth muscle cells.

Seishi AiharaToshiaki NakanoKumiko TorisuTakanari Kitazono

Published in: Clinical and experimental nephrology (2022)

The GDPs of PD effluent cause an imbalance of angiogenic factors in endothelial cells and vascular smooth muscle cells that may lead to immature angiogenesis in the peritoneum.

Keyphrases

vascular smooth muscle cells
endothelial cells
peritoneal dialysis
angiotensin ii
end stage renal disease
vascular endothelial growth factor
high glucose
chronic kidney disease
wastewater treatment
blood pressure
metabolic syndrome
insulin resistance