Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers.

Amy Jamieson Juliana Sobral de Barros Dawn R Cochrane J Maxwell Douglas Sameer Shankar Branden J Lynch Samuel C Y Leung Spencer D Martin Janine Senz Amy Lum Yvette Drew C Blake Gilks David G Huntsman Jessica Nell McAlpine

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

sWGS and targeted sequencing identified therapeutic opportunities in 75% of patients with p53abn endometrial cancer. Further research is needed to determine the efficacy of treatments targeting these identified pathways within p53abn endometrial cancers.

Keyphrases

endometrial cancer
cancer therapy
single cell
genome wide
young adults