Cliniatines A-C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase.

Yusuke HirasawaTomoko TanakaShiro HirasawaChin Piow WongNahoko UchiyamaToshio KanedaYukihiro GodaHiroshi Morita

Published in: Journal of natural medicines (2021)

Cliniatines A-C (1-3), three new Amaryllidaceae alkaloids, consisting of 2,6-dimetylpyridine and lycorine-type and/or galanthamine-type were isolated from Clivia miniata (Lindl.) Bosse. The structures and absolute configurations of 1-3 were elucidated based on spectroscopic data and chemical correlation. Cliniatines A-C showed moderate inhibitory activity against acetylcholinesterase.

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