"Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction".
Federica PapaccioBlanca García-MicoFrancisco Gimeno-ValienteManuel Cabeza-SeguraValentina GambardellaMaría Fernanda Gutiérrez-BravoClara Alfaro-CervellóCarolina Martinez-CiarpagliniPilar Rentero-GarridoSheila Zúñiga-TrejosJuan Antonio Carbonell-AsinsTania FleitasSusana RosellóMarisol HuertaManuel M Sánchez Del PinoLuís SabaterDesamparados RodaNoelia TarazonaAndres CervantesJosefa CastilloPublished in: Journal of experimental & clinical cancer research : CR (2023)
Our strategy of integrating PDOs drug sensitivity with SWATH-mass spectrometry and RNA-seq allowed us to identify different baseline proteins and gene expression profiles with the potential to predict treatment response/resistance and to help in the development of effective and personalized cancer therapeutics.