"Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction".

Federica PapaccioBlanca García-MicoFrancisco Gimeno-ValienteManuel Cabeza-SeguraValentina GambardellaMaría Fernanda Gutiérrez-BravoClara Alfaro-CervellóCarolina Martinez-CiarpagliniPilar Rentero-GarridoSheila Zúñiga-TrejosJuan Antonio Carbonell-AsinsTania FleitasSusana RosellóMarisol HuertaManuel M Sánchez Del PinoLuís SabaterDesamparados RodaNoelia TarazonaAndres CervantesJosefa Castillo

Published in: Journal of experimental & clinical cancer research : CR (2023)

Our strategy of integrating PDOs drug sensitivity with SWATH-mass spectrometry and RNA-seq allowed us to identify different baseline proteins and gene expression profiles with the potential to predict treatment response/resistance and to help in the development of effective and personalized cancer therapeutics.

Keyphrases

rna seq
single cell
mass spectrometry
papillary thyroid
small molecule
genome wide
copy number
squamous cell
high resolution
drug induced
emergency department
dna methylation
squamous cell carcinoma
high performance liquid chromatography
human health
lymph node metastasis
genome wide analysis