Gongronema latifolium Benth. leaf extract attenuates diabetes-induced neuropathy via inhibition of cognitive, oxidative stress and inflammatory response.
Oluwafemi Adeleke OjoMary Abiola OkesolaLisa Ilobekemen EkakitieBasiru Olaitan AjiboyeBabatunji Emmanuel OyinloyePrecious Eseose AgboinghaleAmos Sunday OnikanniPublished in: Journal of the science of food and agriculture (2020)
This study showed that leaf extract of G. latifolium improved antioxidant defense against oxidative stress. It displays a neuroprotective effect resulting in the modulation of brain neurotransmitters, which could be considered as a promising treatment therapy. © 2020 Society of Chemical Industry.
Keyphrases
- oxidative stress
- diabetic rats
- inflammatory response
- ischemia reperfusion injury
- dna damage
- type diabetes
- induced apoptosis
- cardiovascular disease
- cerebral ischemia
- high glucose
- white matter
- resting state
- glycemic control
- lipopolysaccharide induced
- toll like receptor
- immune response
- stem cells
- endothelial cells
- signaling pathway
- functional connectivity
- insulin resistance
- anti inflammatory
- mesenchymal stem cells
- subarachnoid hemorrhage
- bone marrow
- blood brain barrier
- smoking cessation
- innate immune