Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation.

Xiaohong YeYun YangJiayue YaoMo WangYixin LiuGuobin XieZhiping ZengXiao-Kun ZhangHu Zhou

Published in: BMC biology (2023)

Our findings unravel an unexpected role of transcription factor RXRα in specific miRNA maturation at post-transcriptional level through pre-miRNA binding, and present a mechanistic insight regarding RXRα role in breast cancer progression.

Keyphrases

transcription factor
dna binding
cell proliferation
long non coding rna
long noncoding rna
binding protein
heat shock