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Estrogen Deficiency Exacerbates Traumatic Heterotopic Ossification in Mice.

Zheng WangYifan WuWanrong YiYifeng YuXue FangZonghuan LiAixi Yu
Published in: Journal of inflammation research (2024)
Estrogen deficiency exacerbated HO formation in the Achilles tenotomy model. These findings might be attributable to the disturbance of the inflammatory response and the activation of TGF-β/SMAD signaling at the injury sites during the early stages of HO development.
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