Tumour-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer.
Chao LinHongyong HeHao LiuRuochen LiYifan ChenYangyang QiQi JiangLingli ChenPeipei ZhangHeng ZhangHe LiWeijuan ZhangYihong SunJiejie XuPublished in: Gut (2019)
CXCL8 is predominantly secreted by macrophages and contributes to the immunosuppressive microenvironment by inducing PD-L1+ macrophages in gastric cancer. CXCL8 inhibitors may drive antitumour response, providing potential therapeutic effects for patients with gastric cancer.
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