Hypoxia-induced neuronal activity in glioma patients polarizes microglia by potentiating RNA m6A demethylation.

Reza Bavarsad Shahripour Wei Qiu Boyan Li Yanhua Qi Shaobo Wang Rongrong Zhao Bo Cheng Xiao Han Hao Du Ziwen Pan Shulin Zhao Jiawei Qiu Gang Li Hao Xue

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

These findings indicated that hypoxic GSC-induced neuron activation promotes GBM progression by polarizing microglia via the exosomal miR-200c-3p/ZC3H13/DUSP9/p-ERK pathway. Levetiracetam, an antileptic drug, blocks the abnormal activation of neurons in GBM and impairs activity-dependent GBM progression.

Keyphrases

cell proliferation
end stage renal disease
inflammatory response
ejection fraction
newly diagnosed
chronic kidney disease
signaling pathway
long non coding rna
neuropathic pain
prognostic factors
emergency department
drug induced
diabetic rats
spinal cord injury
pi k akt
stress induced