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Suppressor-type TERT mutations associated with recurrence in ovarian clear cell carcinoma.

Tatsuya KobayashiKyoko NishikimiAkira MitsuhashiHongying PiaoAyumu MatsuokaSatoyo OtsukaShinichi TateMakio ShozuHirokazu Usui
Published in: Genes, chromosomes & cancer (2023)
Several cancers harbor "enhancer-type" mutations of the telomerase reverse transcriptase (TERT) promoter for immortalization. Here, we report that 8.6% (8/93) of ovarian clear cell carcinomas (OCCCs) possess the "suppressor-type" TERT promoter mutation. The recurrence rate of OCCCs with "suppressor-type" TERT promoter mutations was 62.5% (5 of 8) and was significantly higher than that of the "unaffected-type" with no mutation (20.8%, 15 of 72) or "enhancer-type" TERT promoter mutations (7.7%, 1 of 13). Our findings show that the acquired suppression of TERT is closely associated with OCCC development and recurrence, indicating the need for further research on telomerase suppression in cancers.
Keyphrases
  • transcription factor
  • dna methylation
  • gene expression
  • clear cell
  • binding protein
  • free survival
  • young adults