PRState: Incorporating genetic ancestry in prostate cancer risk scores for men of African ancestry.

Meghana S PagadalaJoshua A LinscottJames V TalwarTyler M SeibertBrent RoseJulie LynchMatthew PanizzonRichard HaugerMoritz H HansenJesse D SammonMatthew H HaynKarim KaderHannah CarterStephen T Ryan

Published in: BMC cancer (2022)

African ancestry-specific PRState improves PrCa prediction in African ancestry groups in ELLIPSE consortium and MVP. This study underscores the need for inclusion of individuals of African ancestry in gene variant discovery to optimize PRSs and identifies African ancestry-specific variants for use in future studies.

Keyphrases

genome wide association study
genome wide
copy number
prostate cancer
small molecule
gene expression
dna methylation
high throughput