NFE2L2 Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells.

Li Guan Dhanya K Nambiar Hongbin Cao Vignesh Viswanathan Shirley Kwok Angela B Y Hui Yuan Hou Rachel D Hildebrand Rie von Eyben Brittany J Holmes Junfei Zhao Christina S Kong Nathan Wamsley Weiruo Zhang Michael B Major Seung W Seol John B Sunwoo David Neil Hayes Maximillian Diehn Quynh-Thu Le

Published in: Cancer research (2023)

NFE2L2 mutations are predictive biomarkers of radioresistance in head and neck cancer and confer sensitivity to glutaminase inhibitors to overcome radioresistance.

Keyphrases

dna damage response
induced apoptosis
cancer stem cells
cell cycle arrest
signaling pathway
bone marrow
dendritic cells
acute myeloid leukemia
endoplasmic reticulum stress
cell death
oxidative stress
immune response
cell proliferation