Adenosine kinase inhibition protects mice from abdominal aortic aneurysm via epigenetic modulation of VSMC inflammation.

Jiean XuZhiping LiuQiuhua YangQian Ma Yaqi ZhouYongfeng CaiDingwei ZhaoGuizhen ZhaoTammy LuKunfu OuyangMei HongHa Won KimHuidong ShiJifeng ZhangDavid FultonClint T Miller Rajeev MalhotraNeal L WeintraubYuqing Huo

Published in: Cardiovascular research (2024)

Our findings reveal a novel role for ADK inhibition in attenuating AAA via epigenetic modulation of key inflammatory genes linked to AAA pathogenesis.

Keyphrases

abdominal aortic aneurysm
dna methylation
genome wide
oxidative stress
gene expression
protein kinase
high fat diet induced
single cell
tyrosine kinase
type diabetes
skeletal muscle
insulin resistance
genome wide identification