A route to virtually unlimited functionalization of water-soluble p-sulfonatocalix[4]arenes.
Alexander GorbunovAnna IskandarovaKirill PuchninValentine G NenajdenkoVladimir KovalevIvan M VatsouroPublished in: Chemical communications (Cambridge, England) (2020)
The functionality of p-sulfonatocalix[4]arenes can be easily extended using the propargylation/CuAAC reaction sequence, which allows the introduction of up to four substituted triazole units to the narrow rims of the macrocycles while maintaining their cone shapes and water solubility and, thus, biomedical applicability.