mNP hyperthermia and hypofractionated radiation activate similar immunogenetic and cytotoxic pathways.

Kayla E A DuvalJames D PetrykMargaret A Crary-BurneyEugene DemidenkoRobert J WagnerP Jack Hoopes

Published in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2021)

This study clearly shows that modest, but commonly used hypofractionated radiation and hyperthermia doses share many important immune and cytotoxic pathways and that combining the treatments, as compared to either treatment alone, results in genetic and biological anti-cancer benefits.

Keyphrases

radiation therapy
radiation induced
small cell lung cancer
gene expression
dna methylation
combination therapy
anti inflammatory