Anticoagulation Versus Antiplatelets in Spontaneous Cervical Artery Dissection: A Systematic Review and Meta-Analysis.
Shadi YaghiLiqi ShuLauren M FletcherFayez H FayadAsghar ShahAna HerningNoail IshoPerla C MansourKareem JoudiBashar ZaidatNoor A MahmoudFeras Abdul KhalekHan XiaoEric D GoldsteinMalik GhannamJames E SieglerSetareh Salehi OmranEkaterina BakradzeThanh N NguyenZafer KeserMuhib KhanReza Bavarsad ShahripourAdam H de HavenonNils HenningerMirjam Rachel HeldnerThalia S FieldYasmin Ninette AzizEva A MistryKaren L FurieStefan T EngelterHugh Stephen MarkusPublished in: Stroke (2024)
In this study of patients with cervical artery dissection, anticoagulation was superior to antiplatelet therapy in reducing ischemic stroke but carried a higher major bleeding risk. This argues for an individualized therapeutic approach incorporating the net clinical benefit of ischemic stroke reduction and bleeding risks. Large randomized clinical trials are required to clarify optimal antithrombotic strategies for management of cervical artery dissection.