Perinatal death by bile acid levels in intrahepatic cholestasis of pregnancy: a systematic review.

Daniele D I MascioJohanna Quist-NelsonMelissa RiegelBrandon GeorgeGabriele SacconeRomana BrunChristian HaslingerChristina HerreraTetsuya KawakitaRichard H LeePierluigi Benedetti PaniciVincenzo Berghella

Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2019)

Maternal TBA ≥100 µmol/L is associated with a 6.8% incidence of perinatal death, most of which (5.9% overall) are stillbirths, while TBA <100 µmol/L are associated with an incidence of perinatal death of 0.3%. It may be reasonable to consider late preterm delivery (at about 35-36 weeks) in women with TBA ≥100 µmol/L.

Keyphrases

pregnant women
risk factors
preterm birth
pregnancy outcomes
gestational age
low birth weight
drug induced
physical activity