Concise Syntheses of Δ12-Prostaglandin J Natural Products via Stereoretentive Metathesis.
Jiaming LiTonia S AhmedChen XuBrian M StoltzRobert H GrubbsPublished in: Journal of the American Chemical Society (2018)
Δ12-Prostaglandin J family is recently discovered and has potent anticancer activity. Concise syntheses of four Δ12-prostaglandin J natural products (7-8 steps in the longest linear sequences) are reported, enabled by convergent stereoretentive cross-metathesis. Exceptional control of alkene geometry was achieved through stereoretention.
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