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Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.

Ylke BruggemanFernanda M C SodréMijke BuitingaChantal MathieuLut OverberghMaria J L Kracht
Published in: Expert opinion on therapeutic targets (2021)
Pan-PAD inhibition is a promising therapeutic strategy for autoimmune diseases. Drugs achieving pan-PAD inhibition were capable of ameliorating, reversing, and preventing clinical symptoms in preclinical mouse models. However, the implications for PADs in key biological processes potentially present a high risk for clinical complications and could hamper the translation of PAD inhibitors to the clinic. We envisage that PAD isozyme-specific inhibitors will improve the understanding the role of PAD isozymes in disease pathology, reduce the risk of side-effects and enhance prospects for future clinical translation.
Keyphrases
  • mouse model
  • primary care
  • current status
  • stem cells
  • cell therapy
  • drug delivery
  • physical activity
  • bone marrow
  • celiac disease