Pharmacokinetic correlates of clinical response in a naturalistic sample of escitalopram-treated patients.

Nicholas KasperkEkkehard HaenChristoph HiemkeThomas FrodlGeorgios SchoretsanitisMichael PaulzenNazar Kuzo

Published in: Expert review of clinical pharmacology (2024)

Patients with low clearance of escitalopram as reflected upon high C/D ratios may be less likely respond to escitalopram. Identifying these patients during dose titration may support clinical decision-making, including switching to a different antidepressant instead of increasing daily dose.

Keyphrases

end stage renal disease
major depressive disorder
ejection fraction
decision making
peritoneal dialysis
prognostic factors
physical activity