Engineered clinical-grade mesenchymal stromal cells combating SARS-CoV-2 omicron variants by secreting effective neutralizing antibodies.

Yanning WangTianyun GaoWanTing LiChenxu TaiYuanyuan XieDong ChenShuo LiuFeifei HuangWenqing WangYuxin ChenBin Wang

Published in: Cell & bioscience (2023)

Our data suggested that engineered clinical-grade MSCs secreting effective neutralizing antibodies as cellular production machines had the potential to combat SARS-CoV-2 infection, which provided a new avenue for effectively treating the older and immunocompromised COVID-19 patients.

Keyphrases

sars cov
respiratory syndrome coronavirus
mesenchymal stem cells
bone marrow
dengue virus
gene expression
copy number
electronic health record
middle aged
machine learning
zika virus
community dwelling
acute respiratory distress syndrome
climate change
extracorporeal membrane oxygenation
mechanical ventilation