Cardioprotective effects of 5-hydroxymethylfurfural mediated by inhibition of L-type Ca2+ currents.

G WölkartA SchrammelC N KoyaniS ScherübelK Zorn-PaulyE MalleB PelzmannM AndräA Ortner Bernd Mayer

Published in: British journal of pharmacology (2017)

Our data revealed a cardioprotective effect of 5-HMF in I/R that is mediated by inhibition of L-type Ca2+ channels. Thus, 5-HMF is suggested as a beneficial additive to cardioplegic solutions, but adverse effects and contraindications of Ca2+ channel blockers have to be considered in therapeutic application of the drug.

Keyphrases

protein kinase
electronic health record
big data
drug induced