Three novel piperidones exhibit tumor-selective cytotoxicity on leukemia cells via protein degradation and stress-mediated mechanisms.

Lisett ContrerasStephanie MedinaAustre Y Schiaffino BustamanteEdgar A BorregoCarlos A ValenzuelaUmashankar DasSubhas S KarkiJonathan R DimmockRenato J Aguilera

Published in: Pharmacological reports : PR (2021)

Taken together, compounds P3, P4, and P5 exhibit strong potential as anticancer drug candidates as shown by strong cytotoxic potential, activation of the intrinsic pathway of apoptosis, and show typical proteasome inhibitor characteristics.

Keyphrases

cell cycle arrest
induced apoptosis
endoplasmic reticulum stress
cell death
oxidative stress
bone marrow
acute myeloid leukemia
human health
pi k akt
risk assessment
protein protein
cell proliferation
amino acid
binding protein
adverse drug