Tendon disorders affect people of all ages, from elite and recreational athletes and workers to elderly patients. After an acute injury, 3 successive phases are described to achieve healing: an inflammatory phase followed by a proliferative phase, and finally by a remodeling phase. Despite this process, healed tendon fails to recover its original mechanical properties. In this review, we proposed to describe the key factors involved in the process such as cells, transcription factors, extracellular matrix components, cytokines and growth factors and vascularization among others. A better understanding of this healing process could help provide new therapeutic approaches to improve patients' recovery while tendon disorders management remains a medical challenge.
Keyphrases
- extracellular matrix
- anterior cruciate ligament reconstruction
- rotator cuff
- end stage renal disease
- transcription factor
- induced apoptosis
- ejection fraction
- chronic kidney disease
- newly diagnosed
- healthcare
- prognostic factors
- liver failure
- oxidative stress
- peritoneal dialysis
- body composition
- cell death
- intensive care unit
- aortic dissection
- drug induced
- acute respiratory distress syndrome
- patient reported