Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers.

Haotian Liao Xing Chen Haichuan Wang Youpei Lin Lu Chen Kefei Yuan Mingheng Liao Hanyu Jiang Jiajie Peng Zhenru Wu Jiwei Huang Jiaxin Li Yong Zeng

Published in: Cancer research (2024)

Characterization of the DNA methylome of intrahepatic cholangiocarcinoma integrated with genomic, transcriptomic, and proteomic analyses uncovers molecular mechanisms affected by genome-wide DNA methylation alterations, providing a resource for identifying potential therapeutic targets.

Keyphrases

dna methylation
genome wide
copy number
single cell
gene expression
circulating tumor
single molecule
rna seq
cell free
human health
risk assessment
nucleic acid