Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer.
Soeren M BuchholzRobert G GoetzeShiv K SinghChristoph Ammer-HerrmenauFrances M RichardsDuncan I JodrellMalte BuchholzPatrick MichlVolker EllenriederElisabeth HessmannAlbrecht NeessePublished in: Cancers (2020)
Macrophages rapidly metabolize gemcitabine in vitro, and pharmacological depletion improves the therapeutic response to gemcitabine in vivo. Our study supports the notion that TAMs might be a promising therapeutic target in PDAC.