L6H21 Protects Against Cognitive Impairment and Brain Pathologies via Toll-like Receptor 4-Myeloid Differentiation Factor 2 Signaling in Prediabetic Rats.

Thura Tun OoNatticha SumneangBenjamin OngnokBusarin ArunsakTitikorn ChunchaiSasiwan KerdphooNattayaporn ApaijaiWasana PratchayasakulGuang LiangSiriporn C Chattipakorn Siripron C Chattipakorn

Published in: British journal of pharmacology (2021)

L6H21 and metformin restored cognition, and attenuated brain pathologies in dose/time-dependent manners. These results indicate a neuroprotective role of MD-2 inhibitor in prediabetes.

Keyphrases

toll like receptor
white matter
cognitive impairment
cerebral ischemia
resting state
nuclear factor
inflammatory response
immune response
functional connectivity
bone marrow
dendritic cells
multiple sclerosis
subarachnoid hemorrhage
mild cognitive impairment
brain injury
blood brain barrier