Gene expression profiling identifies FLT3 mutation-like cases in wild-type FLT3 acute myeloid leukemia.
Adrián Mosquera OrgueiraAndrés Peleteiro RaíndoMiguel Cid LópezBeatriz Antelo RodríguezJosé Ángel Díaz AriasRoi Ferreiro FerroNatalia Alonso VenceÁngeles Bendaña LópezAitor Abuín BlancoLaura Bao PérezPaula Melero ValentínMarta Sonia González PérezClaudio CerchioneGiovanni MartinelliPau Montesinos FernándezManuel Mateo Pérez EncinasJosé Luis Bello LópezPublished in: PloS one (2021)
We identified a FLT3 mutation-like gene expression pattern in AML which was highly enriched in NPM1 and DNMT3A mutations. Future analysis about the predictive role of this biomarker among wild-type FLT3 patients treated with FLT3 inhibitors is envisaged.