Intra-heterogeneity in transcription and chemoresistant property of leukemia-initiating cells in murine Setd2-/- acute myeloid leukemia.

Jiachun SongLongting DuPing LiuFuhui WangBo ZhangYinyin XieJing LuYi JinYan ZhouGang LvJianmin ZhangSaijuan ChenZhu ChenXiao-Jian SunYuanliang ZhangQiu-Hua Huang

Published in: Cancer communications (London, England) (2021)

This study identified two cell subsets enriched for LICs in murine Setd2-/- -AML and disclosed the transcriptional and functional heterogeneity of LICs, revealing that the coexistence of different types of LICs in this model brings about diverse drug response.

Keyphrases

acute myeloid leukemia
single cell
induced apoptosis
allogeneic hematopoietic stem cell transplantation
transcription factor
gene expression
stem cells
endoplasmic reticulum stress
cell proliferation
drug induced
adverse drug
acute lymphoblastic leukemia
cell death
heat shock protein