Combined abdominal heterotopic heart and aorta transplant model in mice.
Hao DunLi YeYuehui ZhuBrian W WongPublished in: PloS one (2020)
This model is presented as a new tool for researchers to investigate transplant immunology and assess immunosuppressive strategies. It is possible to share a common anastomotic stoma on the recipient abdominal aorta to reconstruct both the aorta graft entrance and heart graft inflow tract. This allows for the study of allogeneic effects on both the aorta and heart from the same animal in a single survival surgery.
Keyphrases
- aortic valve
- pulmonary artery
- heart failure
- atrial fibrillation
- minimally invasive
- stem cell transplantation
- coronary artery
- pulmonary hypertension
- bone marrow
- pulmonary arterial hypertension
- aortic dissection
- rectal cancer
- type diabetes
- metabolic syndrome
- acute coronary syndrome
- low dose
- skeletal muscle
- insulin resistance
- high fat diet induced
- high dose
- hematopoietic stem cell