HER2 assessment by bright-field dual in situ hybridization in cell blocks of recurrent and metastatic breast carcinoma.
Marcia EdelweissAna Paula Martins SebastiaoHandy OenMihaela KracunRene SerretteDara S RossPublished in: Cancer cytopathology (2019)
All methods of HER2 evaluation were found to accurately identify the amplification status. DISH can be used in tandem with IHC as a reflex assay instead of FISH and is an efficient and reliable method with which to determine HER2 amplification in formalin-fixed CBs.