Decrease in treatment intensity predicts worse outcome in patients with locally advanced head and neck squamous cell carcinoma undergoing radiochemotherapy.
S MollnarP PondorferA-K KasparekS ReinischF MoikM StotzM HalmJ SzkanderaA TerbuchF EisnerA GergerK S KappR PartlS VasicekT WeilandM PichlerH StögerD ThurnherFlorian PoschPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2020)
Reductions of radiotherapy dose were associated with impaired long-term outcomes, whereas reductions in chemotherapy intensity were not. This suggests that toxicities during RCT should be primarily managed by modifying chemotherapy rather than radiotherapy.